Four New Polyprenylated Acylphloroglucinols from Hypericum perforatum L.

Hyperforatums A-D (1-4), four new polyprenylated acylphloroglucinols, together with 13 known compounds were isolated and identified from the aerial parts of Hypericum perforatum L. (St. John's wort). Their structures were confirmed with a comprehensive analysis comprising spectroscopic methods, including 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. Hyperforatum A featured an unusual chromene-1,4-dione bicyclic system, and hyperforatums B and C were two rare monocyclic PPAPs with five-membered furanone cores. Compound 1 exhibited a moderate inhibition effect on NO production in BV-2 microglial cells stimulated by LPS.

Evaluation of the correlation between depression and physical activity among older persons with osteoporosis: a cross-sectional study.

Background: Osteoporosis is a common chronic disease in older persons. Physical activity can prevent chronic diseases as well as many diseases associated with aging. Older persons often suffer from depression and other psychological problems. However, there are few studies on the correlation between depression and physical activity in older persons with osteoporosis in China. Methods: This cross-sectional study was conducted from June 1 to December 28, 2021. A total of 207 subjects who met the inclusion and were exclusion criteria were selected from the outpatient department of West China Hospital and evaluated using a self-designed demographic data questionnaire, the Self-rating Depression Scale (SDS), and the Physical Activity Scale for the Elderly (PASE). Multivariate linear regression was performed to analyze the factors affecting physical activity, and multivariate logistic regression analysis was performed to analyze the factors affecting depression. Spearman's correlation coefficients were calculated to analyze the correlation between depression and physical activity in older persons with osteoporosis. Results: A total of 173 valid questionnaires were statistically analyzed. A total of 122 (70.5%) participants were identified as having depression (SDS ≥ 50 points). The median depression score was 62.5 (24.38), and the median PASE score was 69.29 (116.64). Multivariate logistic regression model results showed that physical activity and pain were the main risk factors for depression in older persons with osteoporosis (p < 0.05). Multivariate linear regression model results showed that gender, participation in social activities, activities of daily living status (ADLs), and depression status were the main risk factors associated with physical activity in older persons with osteoporosis (p < 0.05). The results of the correlation analysis showed that physical activity was negatively correlated with depression (R = -0.510, p = 0.000). Conclusion: We found that depression was negatively correlated with physical activity in older persons with osteoporosis in China. This means that the less physical activity there is, the more serious the depression status and having depression may result in reduced physical activity in older persons with osteoporosis. To better help older persons with osteoporosis, medical staff should give more attention to influencing factors of depression and physical activity.

[Application of Risk Management Combined With Precision Nursing in Physical Function Maintenance and Safety Management of Older Patients With Chronic Diseases].

Objective: To examine the application effect of risk management combined with precision nursing in the maintenance of physical functions and the safety management of older patients with chronic diseases and to provide the basis for the formulation of physical function maintenance and fall prevention programs for older inpatients with chronic diseases. Methods: The control group and the observation group were randomly selected by cluster sampling from geriatric wards of similar conditions in West China University, Sichuan University. The control group received conventional nursing care and the observation group had risk management combined with precision nursing on top of the conventional nursing care. The primary outcome indicator was activities of daily living (ADL). The secondary outcome indicators were the whole-day ambulation time and infusion time, the incidence of falls, and length-of-stay among patients. Results: A total of 109 patients in the control group and 110 patients in the observation group completed the study. At the time of admission, there was no statistically significant difference between the ADL scores of the two groups ( P>0.05). Among the patients in the intervention group, the post-intervention ADL scores of the observation group (75.74±22.71) were higher than the pre-intervention ADL scores (68.74±17.32) and the difference was statistically significant ( t=2.435, P<0.05). Among the patients in the control group, the post-intervention ADL scores of the control group (70.36±21.90) were higher than the pre-intervention ADL scores (69.14±18.29) and the difference was not statistically significant ( t=0.549, P>0.05). In addition, the post-intervention ADL score of the observation group was higher than that of the control group, and the difference was statistically significant ( t=2.973, P<0.05). After intervention, patients in the observation group had higher whole-day ambulation time during hospitalization (7.35±2.07) than those in the control group did (4.11±2.62), showing significant difference ( t=1.508, P<0.05). The whole-day infusion time during hospitalization of the observation group (1.68±0.19) was lower than that of the control group (2.39±0.31), showing significant difference ( t=-2.339, P<0.05). There was no significant difference in the incidence of falls or the length-of-stay between the two groups ( P>0.05). Conclusion: Risk management combined with precision nursing helps improve patients' ability to perform activities of daily in older patients with chronic diseases, increase their whole-day ambulation time, and reduce the whole-day infusion time without increasing the incidence of falls, which has a positive effect on physical function maintenance and fall prevention in hospital safety management of older patients with chronic diseases.

Corrigendum: Evaluation of the correlation between depression and physical activity among older persons with osteoporosis: a cross-sectional study.

[This corrects the article DOI: 10.3389/fpsyt.2023.1193072.].